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Lawsuits now pending around the country allege that patients developed severe vision problems after using these medications and were not adequately warned about the risk

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Quick Takeaways Human sleep trials used 25 nmol/kg IV for 7 consecutive nights The commonly used 100250 mcg subcutaneous protocol lacks direct clinical validation DSIP demonstrates an unusually wide safety margin in animal and human research Most evidence comes from small 1980s pilot studies, not modern RCTs What DSIP Actually Is (And Why Its Misunderstood) DSIP is a nine-amino-acid neuropeptide first isolated in 1977 from the cerebral venous blood of sleeping rabbits

Cell Death Differ 25(3):486541

However, when the rats were IV injected 120 microg/kg of DSIP prior to being put in hypoxic conditions it was found that the stress-induced decrease in mitochondrial respiratory activity was completely eliminated